3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

Base Information

Chemical Name:3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester
CAS No.:1392839-98-3
Molecular Formula:C₁₈H₁₂BrN₃O₄
Molecular Weight:414.215
Hs Code.:

Synonyms:3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

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Chemical Property of 3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

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Technology Process of 3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

There total 5 articles about 3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392839-97-2
5-bromo-1-(4-cyano-benzyl)-2-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester

: 1392839-98-3
3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

Guidance literature:: 5-bromo-1-(4-cyano-benzyl)-2-{[methoxycarbonylmethyl-(toluene-4-sulfonyl)-amino]-methyl}-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester; With sodium methylate; In methanol; at 20 ℃; for 16h; Cooling with ice;

With hydrogenchloride; In methanol; water;

Reference yield:

: 10406-25-4
4-aminobenzyl cyanide

: 1392839-98-3
3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol / 2 h / Reflux

1.2: 48 h / Reflux

2.1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

3.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

4.1: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: sodium methylate / methanol / 16 h / 20 °C / Cooling with ice

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4-[1-(4-cyano-benzylamino)-ethylidene]-pent-2-enedioic acid dimethyl ester

: 1392839-98-3
3-bromo-1-(4-cyano-benzyl)-5-hydroxy-2-oxo-1,2-dihydro-[1,7]-naphthyridine-6-carboxylicacid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: sodium methylate; N-Bromosuccinimide / methanol / 1 h / Reflux

2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 16 h / Reflux

3: potassium carbonate; sodium iodide / N,N-dimethyl-formamide / 16 h / 20 °C

4: sodium methylate / methanol / 16 h / 20 °C / Cooling with ice

With N-Bromosuccinimide; sodium methylate; potassium carbonate; sodium iodide; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide;