1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone

Base Information

Chemical Name:1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone
CAS No.:120568-87-8
Molecular Formula:C₁₀H₁₂F₃NO
Molecular Weight:219.207
Hs Code.:
DSSTox Substance ID:DTXSID90556208
Wikidata:Q82437701
Mol file:120568-87-8.mol

Synonyms:120568-87-8;1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone;DTXSID90556208;Pyrrolidine,3,4-diethenyl-1-(trifluoroacetyl)-,cis-(9ci);1-[(3R,4S)-3,4-Diethenylpyrrolidin-1-yl]-2,2,2-trifluoroethan-1-one

Suppliers and Price of 1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone

Chemical Property:

PSA：20.31000
LogP:1.93320
XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:219.08709849
Heavy Atom Count:15
Complexity:269

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=CC1CN(CC1C=C)C(=O)C(F)(F)F
Isomeric SMILES:C=C[C@H]1CN(C[C@H]1C=C)C(=O)C(F)(F)F

Technology Process of 1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone

There total 12 articles about 1-[(3R,4S)-3,4-Bis(ethenyl)pyrrolidin-1-yl]-2,2,2-trifluoroethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 120568-80-1
(Z)-N-crotyltrifluoroacetamide

: 120568-87-8
1-((3S,4R)-3,4-Divinyl-pyrrolidin-1-yl)-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, RT, 5 h

2: Pd(PPh₃)4 / acetic acid / 1.9 h / 80 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid;
DOI:10.1016/S0040-4039(00)80587-0

Reference yield:

: 120568-81-2
(E)-N-crotyltrifluoroacetamide

: 120568-86-7,120568-87-8
1-((3R,4R)-3,4-Divinyl-pyrrolidin-1-yl)-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, RT, 5 h

2: Pd(PPh₃)4 / acetic acid / 2.5 h / 80 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid;
DOI:10.1016/S0040-4039(00)80587-0

Reference yield:

: 120568-80-1
(Z)-N-crotyltrifluoroacetamide

: 120568-86-7,120568-87-8
1-((3R,4R)-3,4-Divinyl-pyrrolidin-1-yl)-2,2,2-trifluoro-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: 1) NaH / 1) DMF, 0 deg C; 2) DMF, RT, 5 h

2: Pd(PPh₃)4 / acetic acid / 1.9 h / 80 °C

With sodium hydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In acetic acid;
DOI:10.1016/S0040-4039(00)80587-0