Picolinonitrile, 6-vinyl- (6CI)

Base Information

• Chemical Name: Picolinonitrile, 6-vinyl- (6CI)
• CAS No.: 120613-15-2
• Molecular Formula: C₈H₆N₂
• Molecular Weight: 130.149
• Mol file: 120613-15-2.mol

Synonyms:Picolinonitrile,6-vinyl- (6CI)

Chemical Property of Picolinonitrile, 6-vinyl- (6CI)

Chemical Property:

• Boiling Point: 248.5±28.0 °C(Predicted)
• PKA: -0.75±0.10(Predicted)
• PSA: 36.68000
• Density: 1.07±0.1 g/cm3(Predicted)
• LogP: 1.59628

Purity/Quality:

6-Vinylpicolinonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Picolinonitrile, 6-vinyl- (6CI)

There total 5 articles about Picolinonitrile, 6-vinyl- (6CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tri-n-butyl(vinyl)tin (7486-35-3) + 6-chloro-pyridine-2-carbonitrile (33252-29-8) → 6-vinylpyridine-2-carbonitrile (120613-15-2)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; for 5h; Reflux;

DOI:10.1016/j.bmc.2009.03.001

Reference yield: 79.0%

6-bromopyridin-2-carbonitrile (122918-25-6) + vinyl acetate (108-05-4,9003-20-7) → 6-vinylpyridine-2-carbonitrile (120613-15-2)

Guidance literature:

With 1,3-bis[(diphenylphosphino)propane]dichloronickel(II); lithium iodide; zinc; at 65 ℃; for 8h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.orglett.1c04018

Reference yield: 78.0%

6-bromopyridin-2-carbonitrile (122918-25-6) + tri-n-butyl(vinyl)tin (7486-35-3) → 6-vinylpyridine-2-carbonitrile (120613-15-2)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; In toluene; for 1.16667h; Inert atmosphere; Reflux;

DOI:10.1039/c0gc00775g

upstream raw materials:

tri-n-butyl(vinyl)tin

6-chloro-pyridine-2-carbonitrile

6-bromopyridin-2-carbonitrile

2,6-Dibromopyridine

Downstream raw materials:

6-cyano-2-pyridinecarboxaldehyde

Refernces

• 1、 -. "FORMS AND COMPOSITIONS OF A BETA ADRENERGIC AGONIST". Paragraph 00439. . Retrieved 2021/12/30.
• 2、 -. "HETEROARYL OREXIN RECEPTOR ANTAGONISTS". Page/Page column 38; 39. . Retrieved 2016/07/05.