1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

Base Information

Chemical Name:1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine
CAS No.:863655-00-9
Molecular Formula:C₃₅H₃₉N₉O₄
Molecular Weight:649.753
Hs Code.:

Synonyms:1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

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Chemical Property of 1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

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Technology Process of 1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

There total 2 articles about 1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 863654-21-1
2-(chloromethyl)-N-phenylquinazoline-4-amine

: 863655-00-9
1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

Guidance literature:: 3-methyl-7-(2-butyn-1-yl)-8-[3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-3,7-dihydro-1H-purine-2,6-dione; With caesium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 0.166667h;

2-(chloromethyl)-N-phenylquinazoline-4-amine; In N,N-dimethyl-formamide; at 80 ℃; for 3.5h;

Reference yield: 65.0%

: 863654-21-1
2-(chloromethyl)-N-phenylquinazoline-4-amine

: 668272-43-3
3-methyl-7-(2-butyn-1-yl)-8-[3-(tert-butyloxycarbonylamino)-piperidin-1-yl]-3,7-dihydro-1H-purine-2,6-dione

: 863655-00-9
1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

Guidance literature:: With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 80 ℃; for 3.66667h;

Reference yield: 81.0%

: 863655-00-9
1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine

: 1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-amino-piperidin-1-yl)-xanthine

Guidance literature:: 1-[(4-phenylamino-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-[3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine; With hydrogenchloride; In dichloromethane; water; isopropyl alcohol; at 20 ℃; for 3h;

With potassium carbonate; In dichloromethane; water; isopropyl alcohol;