5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

Base Information

Chemical Name:5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine
CAS No.:1310531-02-2
Molecular Formula:C₂₅H₂₆N₈
Molecular Weight:438.535
Hs Code.:

Synonyms:5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

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Chemical Property of 5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

Chemical Property:

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Technology Process of 5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

There total 8 articles about 5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 402960-38-7
5-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)pyrimidin-2-ylamine

: 1310532-36-5
5-bromo-1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazole

: 1310531-02-2
5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 110 ℃; for 3h; Sealed; Inert atmosphere;

Reference yield:

: 364-73-8
4-Bromo-1-fluoro-2-nitrobenzene

: 1310531-02-2
5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 8 steps

1: tetrahydrofuran / 16 h / 60 °C

2: zinc; ammonium formate / water; methanol / 2 h / 70 °C

3: Oxone / N,N-dimethyl-formamide; water / 2 h / 20 °C

4: ammonium hydroxide; dihydrogen peroxide / water; methanol / 3 h / 20 °C

5: 5 h / 110 °C

6: hydrazine; acetic acid / water / 2 h / 20 °C

7: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

8: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 3 h / 110 °C / Sealed; Inert atmosphere

With Oxone; ammonium hydroxide; dihydrogen peroxide; ammonium formate; sodium carbonate; potassium carbonate; acetic acid; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1135351-95-9
4-bromo-N-(tert-butyl)-2-nitroaniline

: 1310531-02-2
5-{1-tert-butyl-2-[2-(1,5-dimethyl-1H-[1,2,4]triazol-3-yl)phenyl]-1H-benzimidazol-5-yl}pyrimidin-2-ylamine

Guidance literature:: Multi-step reaction with 7 steps

1: zinc; ammonium formate / water; methanol / 2 h / 70 °C

2: Oxone / N,N-dimethyl-formamide; water / 2 h / 20 °C

3: ammonium hydroxide; dihydrogen peroxide / water; methanol / 3 h / 20 °C

4: 5 h / 110 °C

5: hydrazine; acetic acid / water / 2 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

7: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 3 h / 110 °C / Sealed; Inert atmosphere

With Oxone; ammonium hydroxide; dihydrogen peroxide; ammonium formate; sodium carbonate; potassium carbonate; acetic acid; hydrazine; zinc; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; N,N-dimethyl-formamide;