(1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine

Base Information

• Chemical Name: (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine
• CAS No.: 104920-46-9
• Molecular Formula: C₂₂H₂₉NO
• Molecular Weight: 323.478
• Mol file: 104920-46-9.mol

Synonyms:(1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine

Chemical Property of (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine

There total 3 articles about (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

(2R,4R)-(2S,4R)-2-cyclohexyl-4-phenyl-1,3-oxazolidine (104920-44-7,104920-45-8) + benzylmagnesium chloride (6921-34-2) → (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine (104920-46-9)

Guidance literature:

In tetrahydrofuran; for 4h; Ambient temperature;

DOI:10.1248/cpb.34.2071

Reference yield:

D-2-phenylglycinol (56613-80-0) → (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine (104920-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.6 percent / anhydrous MgSO₄ / CH₂Cl₂ / 1 h / Ambient temperature

2: 87 percent / tetrahydrofuran / 4 h / Ambient temperature

With magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.34.2071

Reference yield:

cyclohexanecarbaldehyde (2043-61-0) → (1R,1'R)-cyclohexyl-N-2'-hydroxy-1'-phenylethyl-2-phenylethylamine (104920-46-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 94.6 percent / anhydrous MgSO₄ / CH₂Cl₂ / 1 h / Ambient temperature

2: 87 percent / tetrahydrofuran / 4 h / Ambient temperature

With magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.34.2071

upstream raw materials:

(2R,4R)-(2S,4R)-2-cyclohexyl-4-phenyl-1,3-oxazolidine

benzylmagnesium chloride

D-2-phenylglycinol

cyclohexanecarbaldehyde

Downstream raw materials:

(R)-1-cyclohexyl-N-cyclopropylmethyl-2-phenylethylamine hydrochloride

(R)-N-cyclopropylmethyl-1-cyclohexyl-N-methyl-2-phenylethylamine hydrochloride

(R)-N-n-propyl-1-cyclohexyl-2-phenylethylamine hydrochloride

(R)-1-cyclohexyl-N-isopropyl-2-phenylethylamine hydrochloride