8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

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Chemical Name:8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate
CAS No.:77632-81-6
Molecular Formula:C₃₃H₄₄F₃NO₇
Molecular Weight:623.71
Hs Code.:

Synonyms:8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

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Chemical Property of 8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

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Technology Process of 8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

There total 31 articles about 8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 65253-04-5
(-)-8-phenylmenthol

: 92180-25-1,92180-26-2
(+/-)-trans-(2,2-diethoxycarbonyl-4-isoprropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetic acid

: 77632-81-6,77698-57-8,92219-19-7,92219-20-0
8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; for 16h; Ambient temperature;
DOI:10.1016/S0040-4020(01)82424-8

Reference yield: 60.0%

: 77632-80-5,77648-70-5
(+)-8-phenylmenthyl(Z)-4,4-diethoxycarbonyl-4--2-butenoate

: 77632-81-6
8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

Guidance literature:: With diethylaluminium chloride; In dichloromethane; at -35 ℃; for 18h;
DOI:10.1002/hlca.19800630729

Reference yield:

: 65253-04-5
(-)-8-phenylmenthol

: 77632-81-6
8-phenylmenthyl trans-(2,2-diethoxycarbonyl-4-isopropenyl-1-trifluoroacetylpyrrolidin-3-yl)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: dicyclohexylcarbodiimide, 4-dimethylaminopyridine

2: t-BuOK / 2-methyl-propan-2-ol

3: NaH / hexamethylphosphoric acid triamide

4: 60 percent / Et₂AlCl / CH₂Cl₂ / 18 h / -35 °C

With dmap; potassium tert-butylate; diethylaluminium chloride; sodium hydride; dicyclohexyl-carbodiimide; In N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; tert-butyl alcohol;
DOI:10.1002/hlca.19800630729