3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

Base Information

Chemical Name:3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride
CAS No.:1411991-98-4
Molecular Formula:C₂₆H₂₆BN₃O₄*ClH
Molecular Weight:491.782
Hs Code.:

Synonyms:3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

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Chemical Property of 3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

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Technology Process of 3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

There total 5 articles about 3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411994-28-9
C₃₂H₃₃BN₂O₄

: 1411991-98-4
3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

Guidance literature:: C₃₂H₃₃BN₂O₄; With hydrogenchloride; In ethanol; at 20 ℃; for 4h;

With ammonia; In methanol; for 12h; Further stages; Sealed tube; Heating;

Reference yield:

: 854237-06-2
3′-bromo-[1,1′-biphenyl]-3-carboxylic acid

: 1411991-98-4
3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride

1.2: 4 h / 65 °C

2.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

3.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

5.1: hydrogenchloride / ethanol / 4 h / 20 °C

5.2: 12 h / Sealed tube; Heating

With hydrogenchloride; dmap; thionyl chloride; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1049118-72-0
methyl 3′-bromo-[1,1′-biphenyl]-3-carboxylate

: 1411991-98-4
3′-(5-carbamimidoyl-2H-spiro[benzofuran-3,4′-piperidine]-1′-ylcarbonyl)biphenyl-3-ylboronic acid hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate / dimethyl sulfoxide / 4 h / 80 °C / Inert atmosphere

2.1: lithium hydroxide; water / tetrahydrofuran / 4 h / 20 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 12 h / 20 °C

4.1: hydrogenchloride / ethanol / 4 h / 20 °C

4.2: 12 h / Sealed tube; Heating

With hydrogenchloride; dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; dimethyl sulfoxide;