N-Boc-N-(4-hydroxybutyl)ethacrynic amide

Base Information

Chemical Name:N-Boc-N-(4-hydroxybutyl)ethacrynic amide
CAS No.:1277190-33-6
Molecular Formula:C₂₂H₂₉Cl₂NO₆
Molecular Weight:474.381
Hs Code.:

Synonyms:N-Boc-N-(4-hydroxybutyl)ethacrynic amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-Boc-N-(4-hydroxybutyl)ethacrynic amide

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Technology Process of N-Boc-N-(4-hydroxybutyl)ethacrynic amide

There total 5 articles about N-Boc-N-(4-hydroxybutyl)ethacrynic amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1277190-32-5
N-Boc-N-[4-(t-butyldimethylsilanyloxy)butyl]ethacrynic amide

: 1277190-33-6
N-Boc-N-(4-hydroxybutyl)ethacrynic amide

Guidance literature:: With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran; for 8h; Inert atmosphere;
DOI:10.1016/j.bmcl.2012.04.091

Reference yield:

: 1277190-31-4
N-[4-(t-butyldimethylsilanyloxy)butyl]ethacrynic amide

: 1277190-33-6
N-Boc-N-(4-hydroxybutyl)ethacrynic amide

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

2: water; tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 16 h / 20 °C

With dmap; tetrabutyl ammonium fluoride; water; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 6463-21-4
ethacrynic acid methyl ester

: 1277190-33-6
N-Boc-N-(4-hydroxybutyl)ethacrynic amide

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / N,N-dimethyl-formamide / 8 h / 55 - 60 °C / Inert atmosphere

2: dmap; pyridine / dichloromethane / 20 °C / Inert atmosphere

3: dmap; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

4: water; tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 16 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; water; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;