(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

Base Information

Chemical Name:(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine
CAS No.:285138-31-0
Molecular Formula:C₁₈H₁₉N₅O₃
Molecular Weight:353.381
Hs Code.:

Synonyms:(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

Chemical Property:

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Technology Process of (1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

There total 1 articles about (1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 132294-28-1
<1S-(1α,2β,3α)>-6-amino-9-<2,3-bis(hydroxymethyl)cyclobutyl>purine 2,3-dibenzoate ester

: 285138-31-0
(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

Guidance literature:: With Lipase MY; In phosphate buffer; acetone; at 36 ℃; for 168h; pH=7.0; Enzymatic reaction;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 285138-31-0
(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

: 283598-26-5
(1'S,2'S,3'R)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}adenine

Guidance literature:: 4,4'-dimethoxytrityl chloride; (1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine; With pyridine; at 20 ℃; for 48h;

With sodium hydroxide; In 1,4-dioxane; methanol; water; at 20 ℃; for 12h;
DOI:10.1016/S0040-4020(00)00162-9

Reference yield:

: 285138-31-0
(1'S,2'S,3'R)-9-[2'-benzoyloxymethyl-3'-(hydroxymethyl)cyclobutyl]adenine

: (1'S,2'S,3'R)-9-{2'-hydroxymethyl-3'-[bis(p-methoxyphenyl)phenylmethyloxymethyl]cyclobutyl}-N⁶-(N,N-dimethylaminomethylene)adenine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Py / 48 h / 20 °C

1.2: NaOH / dioxane; methanol; H₂O / 12 h / 20 °C

2.1: methanol / 12 h / 20 °C

With pyridine; In methanol; 1.1: Substitution / 1.2: Hydrolysis / 2.1: Condensation;
DOI:10.1016/S0040-4020(00)00162-9