tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

Base Information

Chemical Name:tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate
CAS No.:1196491-69-6
Molecular Formula:C₂₁H₂₉BrN₂O₆S
Molecular Weight:517.441
Hs Code.:

Synonyms:tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

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Chemical Property of tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

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Technology Process of tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

There total 6 articles about tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1196490-85-3
C₃₄H₃₄BrN₂O₄PS

: 1196491-69-6
tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 12h;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1349901-42-3
C₁₆H₂₁BrN₂O₄S

: 1196491-69-6
tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo2018872

Reference yield:

: 1196491-67-4
N-[(3aS,4R,5S,7aS)-5-azido-7-bromo-2,2-dimethyl-3a,4,5,7a-tetrahydro-1,3-benzodioxol-4-yl]-4-methylbenzenesulfonamide

: 1196491-69-6
tert-butyl ((3aS,4R,5S,7aS)-7-bromo-2,2-dimethyl-4-([(4-methylphenyl)sulfonyl]amino)-3a,4,5,7a-tetrahydro-1,3-benzodioxol-5-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / tetrahydrofuran; water / 12 h

2: triethylamine / dichloromethane / 12 h / 0 °C / Inert atmosphere

With triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; water; 1: Staudinger reaction;
DOI:10.1021/jo2018872