N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Base Information

Chemical Name:N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine
CAS No.:945396-41-8
Molecular Formula:C₁₉H₁₅ClN₄O₃S
Molecular Weight:414.872
Hs Code.:

Synonyms:N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Suppliers and Price of N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

There total 5 articles about N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 945396-93-0
4-chloro-N-[3-(methylsulfonyl)phenyl]-2-pyrimidinamine

: 379230-43-0
6-chloro-1-benzofuran-7-amine

: 945396-41-8
N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Guidance literature:: With hydrogenchloride; In diethyl ether; isopropyl alcohol; at 90 ℃; for 1h;

Reference yield:

: 945396-92-9
N-(4-chloropyrimidin-2-yl)-N-(3-methylsulfanylphenyl)formamide

: 945396-41-8
N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; methanol / tetrahydrofuran / 0.25 h / 17 - 25 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 17 - 25 °C / Cooling with ice

3: hydrogenchloride / isopropyl alcohol; diethyl ether / 1 h / 90 °C

With hydrogenchloride; methanol; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol;

Reference yield:

: 1783-81-9
3-methylmercaptoaniline

: 945396-41-8
N'-(6-chlorobenzofuran-7-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 2 h / Reflux

2.1: sodium hydride / mineral oil / 0.17 h / 0 °C

2.2: 1 h / 17 - 25 °C

3.1: sodium hydroxide; methanol / tetrahydrofuran / 0.25 h / 17 - 25 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 17 - 25 °C / Cooling with ice

5.1: hydrogenchloride / isopropyl alcohol; diethyl ether / 1 h / 90 °C

With hydrogenchloride; methanol; sodium hydride; 3-chloro-benzenecarboperoxoic acid; sodium hydroxide; In tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol; mineral oil;