3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine)

Base Information

• Chemical Name: 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine)
• CAS No.: 1034146-27-4
• Molecular Formula: C₄₉H₄₉N₇O₁₁
• Molecular Weight: 911.968

Synonyms:3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine)

Chemical Property of 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine)

Chemical Property:

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Technology Process of 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine)

There total 2 articles about 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-2'-deoxyadenosine) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH2-5'-(6-N-benzoyl-3'-O-(methoxyacetyl)-2'-deoxyadenosine) (1034146-26-3) → 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH2-5'-(6-N-benzoyl-2'-deoxyadenosine) (1034146-27-4)

Guidance literature:

With potassium tert-butylate; In methanol; dichloromethane; at 20 ℃; for 0.25h; Inert atmosphere;

DOI:10.1002/ejoc.200701178

Reference yield: 75.0%

C28H31N7O9 (1189166-88-8) + 4,4'-dimethoxytrityl chloride (40615-36-9) → 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH2-5'-(6-N-benzoyl-2'-deoxyadenosine) (1034146-27-4)

Guidance literature:

In pyridine; at 20 ℃; for 20h; Inert atmosphere;

DOI:10.1021/ja904926e

Reference yield: 66.0%

3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH2-5'-(6-N-benzoyl-2'-deoxyadenosine) (1034146-27-4) + 2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine (124482-92-4,89992-70-1) → 3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH2-5'-(6-N-benzoyl-3'-O-[(2-cyanoethyl)(diisopropylamino)phosphanyl]-2'-deoxyadenosine) (1034146-22-9)

Guidance literature:

With dmap; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.416667h; Inert atmosphere;

DOI:10.1002/ejoc.200701178

upstream raw materials:

3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-3'-O-(methoxyacetyl)-2'-deoxyadenosine)

C₂₈H₃₁N₇O₉

4,4'-dimethoxytrityl chloride

Downstream raw materials:

3'-(5'-O-(4,4'-dimethoxytrityl)-thymidine)-CH₂-5'-(6-N-benzoyl-3'-O-[(2-cyanoethyl)(diisopropylamino)phosphanyl]-2'-deoxyadenosine)

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