N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit

Base Information

Chemical Name:N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit
CAS No.:121058-86-4
Molecular Formula:C54H68 N7 O9 P Si
Molecular Weight:1018.23
Hs Code.:

Synonyms:N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit

Suppliers and Price of N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit

Chemical Property:

PSA：187.16000
LogP:10.89170

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit

There total 7 articles about N-blocked-5'-O-DMT-2'-O-TBDMS CED adenosine phosphoramidit which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10457-15-5
O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine

: 121058-86-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxybenzotriazole / acetonitrile / 17 h / Ambient temperature

2: pyridine / 5 °C

3: imidazole / pyridine / Ambient temperature

4: diisopropylethylamine / DMAP / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; pyridine; acetonitrile;
DOI:10.1016/S0040-4039(01)80326-9

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 121058-86-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 5 °C

2: imidazole / pyridine / Ambient temperature

3: diisopropylethylamine / DMAP / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(01)80326-9

Reference yield:

: 121076-16-2
5'-O-dimethoxytrityl-N₆-phenoxyacetyladenosine

: 121058-86-4
Diisopropyl-phosphoramidous acid (2R,3R,4R,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[6-(2-phenoxy-acetylamino)-purin-9-yl]-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: imidazole / pyridine / Ambient temperature

2: diisopropylethylamine / DMAP / tetrahydrofuran / 3 h / Ambient temperature

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; pyridine;
DOI:10.1016/S0040-4039(01)80326-9