N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Base Information

• Chemical Name: N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite
• CAS No.: 121058-88-6
• Molecular Formula: C47H64 N5 O9 P Si
• Molecular Weight: 902.113
• Hs Code.: 29349990

Synonyms:5'-O-DMT-2'-TBDMS-rC(N-Ac)-3'-CEDPA

Chemical Property of N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

Chemical Property:

• PKA: 10.16±0.20(Predicted)
• PSA: 169.22000
• LogP: 9.24958
• Storage Temp.: ?20°C

Purity/Quality:

99% ^*data from raw suppliers

DMT-2′O-TBDMS-rC(ac) Phosphoramidite ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: DMT-2′O-TBDMS-rC(ac) Phosphoramidite was used for inverse electron-demand Diels-Alder reactions for selective and efficient labeling of RNA.

Technology Process of N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite

There total 11 articles about N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-[(tert-butyl)dimethylsilyl]cytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

→ (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)met hoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite (121058-88-6)

Guidance literature:

Reference yield: 84.0%

→ 5'-O-Dimethoxytrityl-2'-O-tert-butyldimethylsilyl-N4-acetylcytidine 3'-N,N-diisoproply(cyanoethyl)phosphoramidite + (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)met hoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite (121058-88-6)

Guidance literature:

Reference yield: 83.0%

→ (2R,3R,4R,5R)-5-(4-acetamido-2-oxopyrimidin-1(2H)-yl)-2-((bis(4-methoxyphenyl)(phenyl)met hoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)tetrahydrofuran-3-yl(2-cyanoethyl)diisopropylphosphoramidite (121058-88-6) + 5'-O-(4,4'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)uridine-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]phosphoramidite (144490-31-3,118362-03-1,131349-31-0,131349-37-6)

Guidance literature:

upstream raw materials:

2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

5'-O-DMTr-2'-O-TBDMS-N4-acetylcytidine

4,4'-dimethoxytrityl chloride

N⁴-acetyl-5'-O-(4,4'-dimethoxytrityl)cytidine

Downstream raw materials:

5'-O-DMTr-2'-O-TBDMS-N4-acetylcytidine

C₄₅H₆₂N₅O₈PSi

C₆₂H₈₀N₁₃O₁₂PSi

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