N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

Base Information

Chemical Name:N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide
CAS No.:1447589-26-5
Molecular Formula:C₃₁H₄₂BrN₃O₅
Molecular Weight:616.596
Hs Code.:

Synonyms:N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

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Chemical Property of N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

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Technology Process of N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

There total 8 articles about N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1711-09-7
3-bromobenzoyl chloride

: 1447589-21-0
C₂₄H₃₉N₃O₄

: 1447589-26-5
N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

Guidance literature:: In dichloromethane; at 0 ℃; for 0.166667h;
DOI:10.1002/ejoc.201300408

Reference yield:

: 1447589-01-6
(2R,3R)-2,3-dimethoxy-3-(2-nitrophenyl)propan-1-amine

: 1447589-26-5
N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

Guidance literature:: Multi-step reaction with 7 steps

1: ethanol / 0.5 h

2: sodium cyanoborohydride; acetic acid / ethanol / 1 h / 0 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 6 h / 0 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.08 h / 20 °C

5: dichloromethane / 0.17 h / 0 °C

6: acetic acid; zinc / ethanol / 0.5 h / 0 °C

7: dichloromethane / 0.17 h / 0 °C

With sodium cyanoborohydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; zinc; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300408

Reference yield:

: 1447589-11-8
C₂₁H₃₅N₃O₅

: 1447589-26-5
N-(2-((1R,2R)-3-((2S,3S)-2-acrylamido-N-isobutyl-3-methylpentanamido)-1,2-dimethoxypropyl)phenyl)-3-bromobenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0.17 h / 0 °C

2: acetic acid; zinc / ethanol / 0.5 h / 0 °C

3: dichloromethane / 0.17 h / 0 °C

With acetic acid; zinc; In ethanol; dichloromethane;
DOI:10.1002/ejoc.201300408