N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Base Information

Chemical Name:N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide
CAS No.:1450643-51-2
Molecular Formula:C₂₄H₃₀FNO₇
Molecular Weight:463.503
Hs Code.:

Synonyms:N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

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Chemical Property of N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

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Technology Process of N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

There total 6 articles about N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₂₈FNO₈

: 1450643-51-2
N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: With methanol; triethylamine; for 12h;
DOI:10.1016/j.ejmech.2017.10.038

Reference yield:

: N-(2-(5-(benzyloxy)-3'-fluoro-6-(methoxymethoxy)-[1,1'-biphenyl]-2-yl)ethyl)acetamide

: 1450643-51-2
N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / 12 h / 20 °C

2: boron trifluoride diethyl etherate / dichloromethane / 0.1 h / 20 °C

3: triethylamine; methanol / 12 h

With methanol; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; triethylamine; In dichloromethane;
DOI:10.1016/j.ejmech.2017.10.038

Reference yield:

: C₁₇H₁₅F₃O₇S

: 1450643-51-2
N-(2-(5-{[(3R,4S,5R)-3,4-dihydroxy-5-methoxy-6,6-dimethyltetrahydro-2H-pyran-2-yl]oxy}-3'-fluoro-6-hydroxy-[1,1'-biphenyl]-2-yl)ethyl)acetamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / Reflux

2.1: ammonium acetate / 4 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 12 h / 0 - 20 °C

4.1: triethylamine / dichloromethane / 0.25 h / 0 °C

4.2: 12 h / 0 - 20 °C

5.1: palladium 10% on activated carbon; hydrogen / 12 h / 20 °C

6.1: boron trifluoride diethyl etherate / dichloromethane / 0.1 h / 20 °C

7.1: triethylamine; methanol / 12 h

With methanol; lithium aluminium tetrahydride; palladium 10% on activated carbon; boron trifluoride diethyl etherate; ammonium acetate; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2017.10.038