2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

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Chemical Name:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide
CAS No.:1453207-77-6
Molecular Formula:C₁₈H₁₈F₂N₆O₄
Molecular Weight:420.376
Hs Code.:

Synonyms:2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

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Chemical Property of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

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Technology Process of 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

There total 4 articles about 2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1453207-61-8
[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetic acid

: 1453207-77-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

Guidance literature:: With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; ammonium chloride; benzotriazol-1-ol; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

: 1453212-33-3
5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]-N-[1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]pyrimidin-2-amine

: 1453207-77-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / methanol; 1,4-dioxane / 6 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

3: sodium hydroxide; water / ethanol; tetrahydrofuran / 5 h / 20 °C

4: triethylamine; ammonium chloride; N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With hydrogenchloride; N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; water; potassium carbonate; ammonium chloride; benzotriazol-1-ol; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1453211-76-1
ethyl [4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetate

: 1453207-77-6
2-[4-({5-[(2,6-difluoro-3,5-dimethoxybenzyl)oxy]pyrimidin-2-yl}amino)-1H-pyrazol-1-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; water / ethanol; tetrahydrofuran / 5 h / 20 °C

2: triethylamine; ammonium chloride; N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 12 h / 20 °C

With N-[3-(diethylamino)propyl]-N'-ethylcarbodiimide hydrochloride; water; ammonium chloride; benzotriazol-1-ol; triethylamine; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;