(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Base Information

Chemical Name:(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester
CAS No.:129439-65-2
Molecular Formula:C₄₄H₇₈BrN₃O₇Si₂
Molecular Weight:897.194
Hs Code.:

(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Synonyms:(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Suppliers and Price of (S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

There total 20 articles about (S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 119706-70-6
(S)-2-{(R)-2-[((S)-2-Amino-propionyl)-methyl-amino]-3-[3-bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-propionylamino}-propionic acid tert-butyl ester

: 117289-84-6
(E)-(2S,6R,8S)-8-{[tert-butyl(dimethyl)silyl]oxy}-2,4,6-trimethylnon-4-enoic acid

: 129439-65-2
(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 5h;

Reference yield:

: 42406-77-9
L-tyrosine benzyl ester

: 129439-65-2
(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 91.2 percent / Et₃N / dioxane; H₂O / 24 h / Ambient temperature

2: 93.3 percent / imidazole / dimethylformamide / 7 h / Ambient temperature

3: 82 percent / NaH / dimethylformamide / 3 h

4: 84.9 percent / TFA / CH₂Cl₂ / 4 h / 0 °C

5: 91 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

6: 86.4 percent / H₂ / 10percent Pd-C / ethanol / 15 h

7: 82.8 percent / N-methylmorpholine, DCC, HOBT / CH₂Cl₂ / 5 h / 0 °C

8: 87 percent / Br₂ / CHCl₃ / 3 h / -5 °C

9: 77 percent / 2,6-lutidine, TBSOTf / CH₂Cl₂ / 2.5 h / Ambient temperature

10: 68 percent / HOBT, DCC / tetrahydrofuran / 5 h / 0 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; hydrogen; bromine; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide;

Reference yield:

: 19391-35-6
N-tert-butoxycarbonyl-L-tyrosine benzyl ester

: 129439-65-2
(S)-2-[(R)-3-[3-Bromo-4-(tert-butyl-dimethyl-silanyloxy)-phenyl]-2-({(S)-2-[(E)-(2S,6R,8S)-8-(tert-butyl-dimethyl-silanyloxy)-2,4,6-trimethyl-non-4-enoylamino]-propionyl}-methyl-amino)-propionylamino]-propionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 93.3 percent / imidazole / dimethylformamide / 7 h / Ambient temperature

2: 82 percent / NaH / dimethylformamide / 3 h

3: 84.9 percent / TFA / CH₂Cl₂ / 4 h / 0 °C

4: 91 percent / Et₃N / CH₂Cl₂ / 10 h / Ambient temperature

5: 86.4 percent / H₂ / 10percent Pd-C / ethanol / 15 h

6: 82.8 percent / N-methylmorpholine, DCC, HOBT / CH₂Cl₂ / 5 h / 0 °C

7: 87 percent / Br₂ / CHCl₃ / 3 h / -5 °C

8: 77 percent / 2,6-lutidine, TBSOTf / CH₂Cl₂ / 2.5 h / Ambient temperature

9: 68 percent / HOBT, DCC / tetrahydrofuran / 5 h / 0 °C

With 4-methyl-morpholine; 1H-imidazole; 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; hydrogen; bromine; sodium hydride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;