3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide

Base Information

• Chemical Name: 3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide
• CAS No.: 227289-23-8
• Molecular Formula: C₂₇H₄₂N₆O₇
• Molecular Weight: 562.666

Synonyms:3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide

Chemical Property of 3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide

Chemical Property:

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Technology Process of 3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide

There total 3 articles about 3-1-(benzyloxycarbonyl)-N²-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Ac-Leu-Ala-Ala-OH + 3-1-(benzyloxycarbonyl)hydrazino>-N,N-(dimethyl)propanamide (227289-22-7) → 3-1-(benzyloxycarbonyl)-N2-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide (227289-23-8)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; for 6h; Ambient temperature;

DOI:10.1016/S0968-0896(99)00006-1

Reference yield:

N,N-Dimethylacrylamide (2680-03-7,68761-83-1) → 3-1-(benzyloxycarbonyl)-N2-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide (227289-23-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 6.5 g / hydrazine monohydrate / methanol / 2 h / Ambient temperature

2: 30 percent / aq. NaOH / diethyl ether / 1 h / 0 - 5 °C

3: 76 percent / benzotriazolyl-N-oxytris(dimethylamino)phosphonium hexafluorophosphate, Et₃N / dimethylformamide / 6 h / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; hydrazine hydrate; triethylamine; In methanol; diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(99)00006-1

Reference yield:

3-hydrazino-N,N-(dimethyl)propanamide (107746-30-5) → 3-1-(benzyloxycarbonyl)-N2-(acetyl-L-leucyl-L-alanyl-L-alanyl)hydrazino>-N,N-(dimethyl)propanamide (227289-23-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 30 percent / aq. NaOH / diethyl ether / 1 h / 0 - 5 °C

2: 76 percent / benzotriazolyl-N-oxytris(dimethylamino)phosphonium hexafluorophosphate, Et₃N / dimethylformamide / 6 h / Ambient temperature

With sodium hydroxide; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In diethyl ether; N,N-dimethyl-formamide;

DOI:10.1016/S0968-0896(99)00006-1

upstream raw materials:

3-1-(benzyloxycarbonyl)hydrazino>-N,N-(dimethyl)propanamide

N,N-Dimethylacrylamide

3-hydrazino-N,N-(dimethyl)propanamide

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