4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide

Base Information

• Chemical Name: 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide
• CAS No.: 1232234-03-5
• Molecular Formula: C₂₅H₂₇ClN₆O₂S
• Molecular Weight: 511.047
• Mol file: 1232234-03-5.mol

Synonyms:4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide

Chemical Property of 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide

There total 7 articles about 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester (288384-72-5) + 4-(3-chloro-phenyl)-2-(6-hydroxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide (1232234-84-2) → 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide (1232234-03-5)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 0.333333h;

Reference yield:

3-(4-methyl-1-piperazinyl)-1-propanol (5317-33-9) → 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide (1232234-03-5)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / dmap / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 100 °C

With pyridine; caesium carbonate; dmap; In N,N-dimethyl-formamide;

Reference yield:

2-(6-benzyloxy-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid (1232234-82-0) → 4-(3-chloro-phenyl)-2-{6-[3-(4-methyl-piperazin-1-yl)-propoxy]-benzoimidazol-1-yl}-thiazole-5-carboxylic acid amide (1232234-03-5)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium chloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C

2: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide / 0.33 h / 100 °C

With boron dimethyl-trifluoro sulphide; ammonium chloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

toluene-4-sulfonic acid 3-(4-methyl-piperazin-1-yl)-propyl ester

4-(3-chloro-phenyl)-2-(6-hydroxy-benzoimidazol-1-yl)-thiazole-5-carboxylic acid amide

3-(4-methyl-1-piperazinyl)-1-propanol

2-(6-benzyloxy-benzoimidazol-1-yl)-4-(3-chloro-phenyl)-thiazole-5-carboxylic acid