4-(Trifluoromethoxy)benzimidamide(HCl)

Base Information

• Chemical Name: 4-(Trifluoromethoxy)benzimidamide(HCl)
• CAS No.: 121219-95-2
• Molecular Formula: C8H7 F3 N2 O . Cl H
• Molecular Weight: 240.613
• Mol file: 121219-95-2.mol

Synonyms:Benzenecarboximidamide,4-(trifluoromethoxy)-, monohydrochloride (9CI); 4-(Trifluoromethoxy)benzamidinehydrochloride

Chemical Property of 4-(Trifluoromethoxy)benzimidamide(HCl)

Chemical Property:

• PSA: 59.10000
• LogP: 3.47130

Purity/Quality:

99%min ^*data from raw suppliers

4-(Trifluoromethoxy)benzamidinehydrochloride 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(Trifluoromethoxy)benzimidamide(HCl)

There total 2 articles about 4-(Trifluoromethoxy)benzimidamide(HCl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-diethoxymethyl-1,1-diethoxynonane (59854-98-7) + ethyl benzimidate hydrochloride (5333-86-8) → 4-(trifluoromethoxy)benzimidamide hydrochloride (121219-95-2) + 2-(p-trifluoromethoxybenzene)-5-heptylpyrimidine

Guidance literature:

In ethanol;

Reference yield:

→ 4-(trifluoromethoxy)benzimidamide hydrochloride (121219-95-2) + 2-(p-trifluoromethoxybenzene)-5-heptylpyrimidine

Guidance literature:

Reference yield: 74.0%

4-(trifluoromethoxy)benzimidamide hydrochloride (121219-95-2) → 3,5-bis(4-(trifluoromethoxy)phenyl)-1H-1,2,4-triazole

Guidance literature:

With iodine; caesium carbonate; In 1,2-dichloro-benzene; at 130 ℃; for 16h; chemoselective reaction;

DOI:10.1016/j.tetlet.2016.04.015

upstream raw materials:

2-diethoxymethyl-1,1-diethoxynonane

ethyl benzimidate hydrochloride

Downstream raw materials:

5-(3-Chloro-thiophen-2-yl)-2-(4-trifluoromethoxy-phenyl)-1H-imidazole

Refernces

• 1、 -. "Substituted phenyl trifluoromethyl ethers". . . Retrieved 2008/06/13.