N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

Base Information

Chemical Name:N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide
CAS No.:129294-64-0
Molecular Formula:C₂₁H₂₅N₅O
Molecular Weight:363.462
Hs Code.:

Synonyms:N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

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Technology Process of N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

There total 14 articles about N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 186795-68-6
1-Methoxymethyl-1H-indazole-3-carboxylic acid (1-benzyl-4-methyl-[1,4]diazepan-6-yl)-amide

: 129294-64-0
N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

Guidance literature:: With hydrogenchloride; for 0.5h; Heating;
DOI:10.1248/cpb.44.2205

Reference yield:

: 186795-64-2
N-(2,2-dimethyl-1,3-dioxan-5-yl)-1H-indazole-3-carboxamide

: 129294-64-0
N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) potassium tert-butoxide / 1.) THF, 5 deg C, 0.5 h, 2.) THF, RT, 16 h

2: 1 N aq. HCl / tetrahydrofuran / 2 h / Ambient temperature

3: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, - 70 deg C, 20 min

4: 2.) NaBH₄ / 1.) MeOH, 5 deg C, 5 min, 2.) MeOH, RT, 2 h

5: 82 percent / 10percent aq. HCl / 0.5 h / Heating

With hydrogenchloride; sodium tetrahydroborate; oxalyl dichloride; potassium tert-butylate; dimethyl sulfoxide; triethylamine; In tetrahydrofuran;
DOI:10.1248/cpb.44.2205

Reference yield:

: 115660-68-9
diindazolo<2,3-a,2',3'-d>pyrazine-7,14-dione

: 129294-64-0
N-(1-benzyl-4-methylhexahydro-1H-1,4-diazepin-6-yl)-1H-indazole-3-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / dimethylformamide / 12 h / Ambient temperature

2: 64 percent / Et₃N / CHCl₃ / 12 h / Ambient temperature

3: 1.) DMSO, oxalyl chloride, 2.) Et₃N / 1.) CH₂Cl₂, -70 deg C, 20 min, 2.) CH₂Cl₂, - 70 deg C, 20 min

4: 2.) NaBH₄ / 1.) MeOH, 5 deg C, 5 min, 2.) MeOH, RT, 2 h

With sodium tetrahydroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In chloroform; N,N-dimethyl-formamide;
DOI:10.1248/cpb.44.2205