(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

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Chemical Name:(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid
CAS No.:1067665-27-3
Molecular Formula:C₂₁H₂₆N₄O₇
Molecular Weight:446.46
Hs Code.:

Synonyms:(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

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Chemical Property of (S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

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Technology Process of (S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

There total 4 articles about (S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

: tert-butyl N^α-[(thymin-1-yl)acetyl]-N^ε-(benzyloxycarbonyl)-L-lysinate

: 1067665-27-3
(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 3.5h;
DOI:10.1016/j.bmc.2005.11.056

Reference yield: 92.0%

: 866251-08-3
C₁₃H₁₁N₅O₃

: 1155-64-2,57705-97-2,67178-46-5,25931-47-9
N₆-[(benzyloxy)carbonyl]-L-lysine

: 1067665-27-3
(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

Guidance literature:: With triethylamine; In water; acetonitrile; at 20 ℃; for 1h;
DOI:10.1039/b806141f

Reference yield:

: 20924-05-4
thymidyl acetic acid

: 1067665-27-3
(S)-6-benzyloxycarbonylamino-2-[2-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetylamino]hexanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 59.7 percent / PyBrop; DIEA / dimethylformamide / 23 h / 0 - 20 °C

2: 99.2 percent / TFA / CH₂Cl₂ / 3.5 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.11.056