allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

Base Information

Chemical Name:allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate
CAS No.:1575819-87-2
Molecular Formula:C₂HF₃O₂*C₃₀H₃₈ClN₅O₃
Molecular Weight:666.14
Hs Code.:

Synonyms:allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

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Chemical Property of allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

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Technology Process of allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

There total 8 articles about allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 42564-51-2
4-fluoro-3-nitrobenzaldehyde

: 1575819-87-2
allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 20 °C

2: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

3: sodium carbonate / water / 24 h / 0 - 20 °C

4: zinc; ammonium chloride / methanol / 1 h / 50 °C

5: ethanol / 3 h / 20 °C / Inert atmosphere

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

7: dichloromethane / 7 h / 0 - 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; zinc; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 1575819-85-0
tert-butyl 2-((5-(((allyloxycarbonyl)((S)-3,3-dimethylbutan-2-yl)amino)methyl)-2-(4-chlorobenzamido)-1H-benzo[d]imidazol-1-yl)methyl)pyrrolidine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1575819-87-2
allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

Guidance literature:: In dichloromethane; at 0 - 20 ℃; for 7h;

Reference yield:

: 1575819-57-6
tert-butyl 2-((4-formyl-2-nitrophenylamino)methyl)pyrrolidine-1-carboxylate

: 1575819-87-2
allyl (2-(4-chlorobenzamido)-1-(pyrrolidin-2-ylmethyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1: acetic acid; sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 6 h / 20 °C / Inert atmosphere

2: sodium carbonate / water / 24 h / 0 - 20 °C

3: zinc; ammonium chloride / methanol / 1 h / 50 °C

4: ethanol / 3 h / 20 °C / Inert atmosphere

5: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 12 h / 20 °C / Inert atmosphere

6: dichloromethane / 7 h / 0 - 20 °C

With sodium tris(acetoxy)borohydride; sodium carbonate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; zinc; In methanol; ethanol; dichloromethane; water; 1,2-dichloro-ethane;