(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

Base Information

Chemical Name:(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid
CAS No.:1410737-39-1
Molecular Formula:C₃₀H₃₂Cl₂FN₃O₄
Molecular Weight:588.506
Hs Code.:

(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

Synonyms:(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

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Chemical Property of (1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

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Technology Process of (1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

There total 10 articles about (1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: C₃₁H₃₄Cl₂FN₃O₄*C₂HF₃O₂

: 1410737-39-1
(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; In tetrahydrofuran; methanol; water; at 50 ℃; for 5h;

Reference yield: 41.0%

: 1410737-15-3
C₃₁H₃₄Cl₂FN₃O₄

: 1410737-39-1
(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

Guidance literature:: With lithium hydroxide monohydrate; sodium hydroxide; In tetrahydrofuran; methanol; water; at 25 ℃; for 2h;

Reference yield:

: C₂₄H₂₃Cl₂FN₂O₃

: 1410737-39-1
(1R,4r)-4-((3'R,4'S,5'R)-6''-chloro-4'-(3-chloro-2-fluorophenyl)-2''-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3''-indoline]-5'-carboxamido)cyclohexane-1-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 0.25 h / 25 °C

2: 1-methyl-1H-imidazole; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate / acetonitrile / 1 h / 25 °C

3: lithium hydroxide monohydrate / water; tetrahydrofuran; methanol / 5 h / 50 °C

With 1-methyl-1H-imidazole; lithium hydroxide monohydrate; N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate; In tetrahydrofuran; methanol; water; acetonitrile;