2-(Hydroxymethyl)-3-methoxyphenol

Base Information

• Chemical Name: 2-(Hydroxymethyl)-3-methoxyphenol
• CAS No.: 59648-30-5
• Molecular Formula: C₈H₁₀O₃
• Molecular Weight: 154.166
• DSSTox Substance ID: DTXSID301296982
• Mol file: 59648-30-5.mol

Synonyms:2-(hydroxymethyl)-3-methoxyphenol;59648-30-5;SCHEMBL11358137;2-Hydroxy-6-methoxybenzenemethanol;DTXSID301296982;AKOS006278373;CS-0378139

Chemical Property of 2-(Hydroxymethyl)-3-methoxyphenol

Chemical Property:

• XLogP3: 1.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 154.062994177
• Heavy Atom Count: 11
• Complexity: 116

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC(=C1CO)O

Technology Process of 2-(Hydroxymethyl)-3-methoxyphenol

There total 3 articles about 2-(Hydroxymethyl)-3-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-hydroxy-6-methoxybenzoic acid (3147-64-6) → 5-methoxysalicylic alcohol (59648-30-5)

Guidance literature:

With sodium tetrahydroborate; boron trifluoride diethyl etherate; In tetrahydrofuran; for 11h; Heating;

DOI:10.1021/ol071085c

Reference yield:

5-methoxy-2-phenyl-4H-benzo[1,3,2]dioxaborinine (70882-24-5) → 5-methoxysalicylic alcohol (59648-30-5)

Guidance literature:

With dihydrogen peroxide; In tetrahydrofuran;

DOI:10.1055/s-1979-28683

Reference yield:

O-methylresorcine (150-19-6) → 5-methoxysalicylic alcohol (59648-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1: EtCO₂H / benzene

2: aq. H₂O₂ / tetrahydrofuran

With dihydrogen peroxide; propionic acid; In tetrahydrofuran; benzene;

DOI:10.1055/s-1979-28683

upstream raw materials:

5-methoxy-2-phenyl-4H-benzo[1,3,2]dioxaborinine

2-hydroxy-6-methoxybenzoic acid

O-methylresorcine

Downstream raw materials:

C₁₇H₁₈O₃