N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

Base Information

Chemical Name:N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide
CAS No.:1542168-64-8
Molecular Formula:C₃₇H₅₃N₃O₄S
Molecular Weight:635.912
Hs Code.:

Synonyms:N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

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Chemical Property of N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

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Technology Process of N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

There total 8 articles about N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1542168-63-7
4-[(3α)-(N-methyl-2-nitrobenzylsulfamoyl)-24-nor-5α,22E-chola-7,22-dien-23-yl]-1,3-dimethylpyridinium iodide

: 1542168-64-8
N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

Guidance literature:: With sodium tetrahydroborate; In ethanol; at 0 - 20 ℃; for 26h; chemoselective reaction;
DOI:10.1016/j.tet.2013.11.065

Reference yield:

: 23738-34-3
(3S,20S)-20-formyl-5α-pregn-7-en-3-yl-acetate

: 1542168-64-8
N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium diisopropyl amide / tetrahydrofuran; hexane / 1 h

1.2: 0.08 h / -78 °C

2.1: triethylamine / chloroform / 1 h / 20 °C

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / chloroform / 72 h / Reflux

4.1: sodium hydroxide; water / tetrahydrofuran / 12 h / Reflux

5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

6.1: acetone / 1 h / Reflux

7.1: sodium tetrahydroborate / ethanol / 26 h / 0 - 20 °C

With sodium tetrahydroborate; water; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; sodium hydroxide; lithium diisopropyl amide; diethylazodicarboxylate; In tetrahydrofuran; ethanol; hexane; chloroform; acetone; 5.1: |Mitsunobu Displacement;
DOI:10.1016/j.tet.2013.11.065

Reference yield:

: 1542168-62-6
N-methyl-N-[(3α)-23-(3-methylpyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-2-nitrobenzenesulfonamide

: 1542168-64-8
N-[(3α)-23-(1,3-dimethyl-1,2,5,6-tetrahydropyridin-4-yl)-24-nor-5α,22E-chola-7,22-dien-3-yl]-N-methyl-2-nitrobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetone / 1 h / Reflux

2: sodium tetrahydroborate / ethanol / 26 h / 0 - 20 °C

With sodium tetrahydroborate; In ethanol; acetone;
DOI:10.1016/j.tet.2013.11.065