4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

Base Information

Chemical Name:4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)
CAS No.:1260487-48-6
Molecular Formula:C₂₈H₂₅ClF₄N₆O₄
Molecular Weight:620.991
Hs Code.:

Synonyms:4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

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Chemical Property of 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

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Technology Process of 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

There total 1 articles about 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1260487-49-7
4-amino-1H-pyrazole-3-carboxylic acid-2,4-dimethoxybenzylamide hydrochloride

: 1260487-50-0
1-(2-chloro-4-trifluoromethylphenyl)-3-(3-fluoro-5-formylphenyl)urea

: 1260487-48-6
4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

Guidance literature:: 4-amino-1H-pyrazole-3-carboxylic acid-2,4-dimethoxybenzylamide hydrochloride; 1-(2-chloro-4-trifluoromethylphenyl)-3-(3-fluoro-5-formylphenyl)urea; With magnesium sulfate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 14h; Inert atmosphere; Reflux;

With sodium cyanoborohydride; In tetrahydrofuran; at 20 - 25 ℃; for 12h;

With water; sodium hydroxide; In tetrahydrofuran;

Reference yield:

: 1260487-48-6
4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide)

: 1260487-47-5
4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-carboxamide

Guidance literature:: 4-{3-[3-(2-chloro-4-trifluoromethylphenyl)ureido]-5-fluorobenzylamino}-1H-pyrazole-3-(2,4-dimethoxybenzylamide); With toluene-4-sulfonic acid; In toluene; for 2h; Reflux;

With potassium hydroxide; In methanol; water; ethyl acetate;