(S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester

Base Information

• Chemical Name: (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester
• CAS No.: 158809-26-8
• Molecular Formula: C₃₁H₃₅F₅O₇S
• Molecular Weight: 646.673
• Mol file: 158809-26-8.mol

Synonyms:(S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester

Chemical Property of (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester

There total 1 articles about (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

pentafluorophenylthiol (771-62-0) + 3α,7α,12α-tris(formyloxy)-23,24-bisnorcholan-22-oic acid → (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester (158809-26-8)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane; 0 deg C, 1 h; room temp., 3 h;

DOI:10.1016/S0040-4039(00)76989-9

Reference yield: 85.0%

cyclohexylamine (108-91-8,157973-60-9) + (S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester (158809-26-8) → Formic acid (3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-17-((S)-1-cyclohexylcarbamoyl-ethyl)-7,12-diformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:

With triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1016/S0040-4039(00)76989-9

Reference yield: 83.0%

(S)-2-((3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-3,7,12-Triformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-thiopropionic acid S-pentafluorophenyl ester (158809-26-8) + benzylamine (100-46-9) → Formic acid (3R,5S,7R,8R,9S,10S,12S,13S,14S,17R)-17-((S)-1-benzylcarbamoyl-ethyl)-7,12-diformyloxy-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:

With triethylamine; In dichloromethane; for 8h; Ambient temperature;

DOI:10.1016/S0040-4039(00)76989-9

upstream raw materials:

pentafluorophenylthiol