Technology Process of 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtho[2,3-d][1,2,3]triazol-1-yl)benzoic acid
There total 6 articles about 4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtho[2,3-d][1,2,3]triazol-1-yl)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphtho[2,3-d][1,2,3]triazol-1-yl)benzoic acid ethyl ester;
With
sodium hydroxide;
In
methanol;
at 60 ℃;
for 2.5h;
With
hydrogenchloride;
In
methanol; water;
DOI:10.1021/ml300055n
- Guidance literature:
-
Multi-step reaction with 3 steps
1: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 20 °C
2: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 1.5 h / 20 °C / Cooling with ice
3: sodium hydroxide / methanol / 2.5 h / 60 °C
With
sulfuric acid; palladium on activated charcoal; hydrogen; sodium hydroxide; sodium nitrite;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/ml300055n
- Guidance literature:
-
Multi-step reaction with 4 steps
1: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; bis(dibenzylideneacetone)-palladium(0) / 1,4-dioxane / 0.5 h / 100 °C
2: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 20 °C
3: sulfuric acid; sodium nitrite / tetrahydrofuran; water / 1.5 h / 20 °C / Cooling with ice
4: sodium hydroxide / methanol / 2.5 h / 60 °C
With
sulfuric acid; palladium on activated charcoal; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; bis(dibenzylideneacetone)-palladium(0); sodium nitrite;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; ethyl acetate;
DOI:10.1021/ml300055n