(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

Base Information

Chemical Name:(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine
CAS No.:884639-59-2
Molecular Formula:C₂₁H₃₁NO₄S
Molecular Weight:393.547
Hs Code.:

Synonyms:(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

Suppliers and Price of (S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of (S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

There total 1 articles about (S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 6089-04-9
3-(tetrahydropyran-2'-yloxy)propyne

: 124575-31-1
(S)-2-isobutyl-1-tosyl-aziridine

: 884639-59-2
(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

Guidance literature:: 3-(tetrahydropyran-2'-yloxy)propyne; With n-butyllithium; In tetrahydrofuran; hexane; at -10 - 20 ℃; for 0.5h;

(S)-2-isobutyl-1-tosyl-aziridine; In tetrahydrofuran; hexane; at 20 ℃; for 22h;
DOI:10.1021/jo052514s

Reference yield: 54.0%

: 884639-59-2
(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

: 884639-63-8
N-(5-hydroxy-1-isobutyl-pent-3-ynyl)-4-methyl-benzenesulfonamide

Guidance literature:: With Amberlyst 15; In methanol; at 20 ℃;
DOI:10.1021/jo052514s

Reference yield:

: 884639-59-2
(S)-1-isobutyl-5-(tetrahydropyran-2-yloxy)-N-toluenesulfonyl-pent-3-ynylamine

: (10S)-10-isobutyl-N-p-toluenesulfonyl-1,5-dithia-9-aza-spiro[5.5]-undec-7-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / Amberlyst 15 / methanol / 20 °C

2: 99 percent / Dess-Martin periodinane / CH₂Cl₂ / 2 h / 0 - 20 °C

3: 78 percent / sodium methoxide / methanol; CH₂Cl₂ / -10 - 20 °C

With Amberlyst 15; sodium methylate; Dess-Martin periodane; In methanol; dichloromethane;
DOI:10.1021/jo052514s