2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Base Information

Chemical Name:2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol
CAS No.:1147015-36-8
Molecular Formula:C₁₇H₁₆N₆O
Molecular Weight:320.354
Hs Code.:

Synonyms:2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

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Chemical Property of 2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

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Technology Process of 2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

There total 4 articles about 2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1142947-77-0
1-(4-((2-methyl-1H-imidazol-1-yl)methyl)phenyl)guanidine

: 1147015-36-8
2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: With sodium methylate; In methanol; at 150 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 52133-67-2
ethyl 2-cyano-4,4-diethoxybutyrate

: 1143571-99-6
(E)-tert-butyl (tert-butoxycarbonylamino)(4-((2-methyl-1H-imidazol-1-yl)methyl)phenylamino)methylenecarbamate

: 1147015-36-8
2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: (E)-tert-butyl (tert-butoxycarbonylamino)(4-((2-methyl-1H-imidazol-1-yl)methyl)phenylamino)methylenecarbamate; With trifluoroacetic acid; In dichloromethane; for 1.5h;

ethyl 2-cyano-4,4-diethoxybutyrate; With sodium methylate; In methanol; at 150 ℃; for 0.5h; Microwave irradiation;

With hydrogenchloride; ammonium hydroxide; more than 3 stages;

Reference yield:

: 1143571-99-6
(E)-tert-butyl (tert-butoxycarbonylamino)(4-((2-methyl-1H-imidazol-1-yl)methyl)phenylamino)methylenecarbamate

: 1147015-36-8
2-[4-(2-methyl-imidazol-1-ylmethyl)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1.5 h

2: sodium methylate / methanol / 0.5 h / 150 °C / Microwave irradiation

With sodium methylate; trifluoroacetic acid; In methanol; dichloromethane;