1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

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Chemical Name:1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol
CAS No.:1578483-79-0
Molecular Formula:C₂₆H₂₈N₈O₂
Molecular Weight:484.561
Hs Code.:

Synonyms:1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

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Chemical Property of 1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

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Technology Process of 1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

There total 5 articles about 1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 14.0%

: 1400287-29-7
4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyaniline

: 1578484-52-2
2-methyl-1-(4-(2-(methylsulfonyl)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)propan-2-ol

: 1578483-79-0
1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: With sodium hydride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; at 160 ℃; for 2h; Microwave irradiation;

Reference yield:

: 352328-41-7
7-chloro-2-methylsulfanylpyrido[2,3-d]pyrimidine

: 1578483-79-0
1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 1 h / 140 °C / Microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

3: sodium hydride / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2 h / 160 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane;

Reference yield:

: 211244-81-4
2-methanesulfanyl-8H-pyrido[2,3-d]pyrimidin-7-one

: 1578483-79-0
1-(4-(2-((4-(1,2-dimethyl-1H-imidazol-5-yl)-2-methoxyphenyl)amino)pyrido[2,3-d]pyrimidin-7-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 16 h / 80 °C / Inert atmosphere

2: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / 1,2-dimethoxyethane / 1 h / 140 °C / Microwave irradiation

3: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C

4: sodium hydride / tetrahydrofuran; 1-methyl-pyrrolidin-2-one / 2 h / 160 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; sodium carbonate; 3-chloro-benzenecarboperoxoic acid; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; 1,2-dimethoxyethane; dichloromethane;