2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

Base Information

Chemical Name:2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester
CAS No.:182156-03-2
Molecular Formula:C₂₁H₃₀O₉
Molecular Weight:426.464
Hs Code.:

Synonyms:2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

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Chemical Property of 2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

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Technology Process of 2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

There total 4 articles about 2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 182156-02-1
2-[1-((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-meth-(E)-ylidene]-succinic acid 1-ethyl ester 4-methyl ester

: 182156-03-2
2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

Guidance literature:: With osmium(VIII) oxide; 4-methylmorpholine N-oxide; In water; acetone; for 168h; Ambient temperature;
DOI:10.1021/jo960963+

Reference yield:

: 65434-72-2
2-(triphenylphosphoranylidene)succinic acid 1-ethyl ester

: 182156-03-2
2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / benzene / 24 h / 25 °C

2: 96 percent / Et₃N / various solvent(s) / 48 h / Ambient temperature

3: 89 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / 168 h / Ambient temperature

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; triethylamine; In water; acetone; benzene;
DOI:10.1021/jo960963+

Reference yield:

: 81028-12-8
(4S,5R)-4-benzyloxymethyl-2,2-dimethyl-1,3-dioxolane-5-carboxaldehyde

: 182156-03-2
2-[((4S,5S)-5-Benzyloxymethyl-2,2-dimethyl-[1,3]dioxolan-4-yl)-hydroxy-methyl]-2-hydroxy-succinic acid 1-ethyl ester 4-methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 80 percent / benzene / 24 h / 25 °C

2: 96 percent / Et₃N / various solvent(s) / 48 h / Ambient temperature

3: 89 percent / OsO₄, N-methylmorpholine N-oxide / acetone; H₂O / 168 h / Ambient temperature

With osmium(VIII) oxide; 4-methylmorpholine N-oxide; triethylamine; In water; acetone; benzene;
DOI:10.1021/jo960963+