(R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID

Base Information

• Chemical Name: (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID
• CAS No.: 121786-36-5
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.196
• Hs Code.: 2924299090
• Mol file: 121786-36-5.mol

Synonyms:(R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID

Chemical Property of (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID

Chemical Property:

• Vapor Pressure: 6.35E-08mmHg at 25°C
• Refractive Index: 1.509
• Boiling Point: 411.5°Cat760mmHg
• PKA: 3.65±0.10(Predicted)
• Flash Point: 202.7°C
• PSA: 66.40000
• Density: 1.211g/cm³
• LogP: 0.76670
• Storage Temp.: 2-8°C

Purity/Quality:

99%min ^*data from raw suppliers

(R)-2-Acetamido-3-cyclopropylpropanoic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID

There total 3 articles about (R)-2-ACETYLAMINO-3-CYCLOPROPYLPROPIONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

N-acetyl-3-cyclopropylalanine (133992-69-5,1374669-61-0) → (R)-2-amino-3-cyclopropylpropanoic acid (121786-39-8,15785-52-1) + (2S)-2-amino-3-cyclopropylpropanoic acid (102735-53-5,15785-52-1) + (R)-2-Acetylamino-3-cyclopropyl-propionic acid (121786-36-5,1374669-61-0) + (S)-2-Acetylamino-3-cyclopropyl-propionic acid (121703-93-3,121786-36-5,133992-69-5,1374669-61-0)

Guidance literature:

With potassium hydroxide; Aspergillus acylase I; Yields of byproduct given; pH 7.5-8.0;

DOI:10.1021/ja00198a055

Reference yield: 50.0%

N-acetyl-3-cyclopropylalanine (133992-69-5,1374669-61-0) → (R)-2-amino-3-cyclopropylpropanoic acid (121786-39-8,15785-52-1) + (2S)-2-amino-3-cyclopropylpropanoic acid (102735-53-5,15785-52-1) + (R)-2-Acetylamino-3-cyclopropyl-propionic acid (121786-36-5,1374669-61-0) + (S)-2-Acetylamino-3-cyclopropyl-propionic acid (121703-93-3,121786-36-5,133992-69-5,1374669-61-0)

Guidance literature:

With potassium hydroxide; Aspergillus acylase I; Yields of byproduct given; pH 7.5-8.0;

DOI:10.1021/ja00198a055

Reference yield:

N-acetyl-3-cyclopropylalanine (133992-69-5,1374669-61-0) → (2S)-2-amino-3-cyclopropylpropanoic acid (102735-53-5,15785-52-1) + (R)-2-Acetylamino-3-cyclopropyl-propionic acid (121786-36-5,1374669-61-0)

Guidance literature:

With potassium hydroxide; potassium phosphate buffer; porcine kidney acylase I; at 40 ℃; relative initial rate of hydrolysis, also with Aspergillus acylase I as a catalyst; with or without CoCl₂;

DOI:10.1021/ja00198a055

upstream raw materials:

N-acetyl-3-cyclopropylalanine

Refernces