(E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Base Information

Chemical Name:(E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile
CAS No.:1352550-14-1
Molecular Formula:C₁₅H₁₇N₃O₂
Molecular Weight:271.319
Hs Code.:

Synonyms:(E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Suppliers and Price of (E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
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Technology Process of (E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

There total 2 articles about (E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 15029-34-2
3-(4-methylpiperazin-1-yl)-3-oxopropanenitrile

: 1352550-14-1
(E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Guidance literature:: With 1-methyl-piperazine; In methanol; at 20 ℃; for 20h;
DOI:10.1016/j.bmc.2011.10.061

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1352550-14-1
(E)-3-(4-hydroxyphenyl)-2-[(4-methylpiperazin-1-yl)-carbonyl]acrylonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 0 - 20 °C / Neat (no solvent)

2: 1-methyl-piperazine / methanol / 20 h / 20 °C

With 1-methyl-piperazine; In methanol; 2: Aldol condensation;
DOI:10.1016/j.bmc.2011.10.061