(S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide

Base Information

• Chemical Name: (S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide
• CAS No.: 310435-49-5
• Molecular Formula: C₂₁H₂₉NO₂SSi
• Molecular Weight: 387.618

Synonyms:(S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide

Chemical Property of (S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide

There total 1 articles about (S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde (130115-07-0) + (S)-p-toluenesulfinimide (188447-91-8) → (SS,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide (310435-49-5)

Guidance literature:

With titanium(IV) tetraethanolate; In dichloromethane; at 20 ℃; for 2h;

DOI:10.1021/jo000559h

Reference yield: 76.0%

diethylaluminium cyanide (5804-85-3) + (SS,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide (310435-49-5) → 4-Methyl-benzenesulfinic acid [(1S,2R)-2-(tert-butyl-dimethyl-silanyloxy)-1-cyano-2-phenyl-ethyl]-amide + (SS,2R,3R)-(+)-N-(p-toluenesulfinyl)-2-amino-[(tert-butyldimethylsilyl)oxy]-3-phenylpropionitrile (310435-64-4)

Guidance literature:

With isopropyl alcohol; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1021/jo000559h

Reference yield:

(SS,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide (310435-49-5) → (2S,3R)-3-phenylserine (6254-48-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / i-PrOH / tetrahydrofuran / -78 - 20 °C

2: 77 percent / 3N HCl / 4 h / Heating

With hydrogenchloride; isopropyl alcohol; In tetrahydrofuran; 1: Addition / 2: Hydrolysis;

DOI:10.1021/jo000559h

upstream raw materials:

(R)-2-(t-butyldimethylsilyloxy)-2-phenylacetaldehyde

(S)-p-toluenesulfinimide

Downstream raw materials:

(S_S,2R,3R)-(+)-N-(p-toluenesulfinyl)-2-amino-[(tert-butyldimethylsilyl)oxy]-3-phenylpropionitrile

(2S,3R)-3-phenylserine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 310435-49-5 (S_S,2R)-(+)-N-[(tert-butyldimethylsilyl)oxy]-2-phenylacetylidene-p-toluenesulfinamide

Send

Send

Metric Ton KG G Pound L ML

Send

Send