Technology Process of (3aS,4S,7aS)-4-Benzyloxymethyl-1-methylene-octahydro-indene
There total 15 articles about (3aS,4S,7aS)-4-Benzyloxymethyl-1-methylene-octahydro-indene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
benzene;
for 3h;
Heating;
further reagent: (dba)3Pd2-CHCl3, BBEDA, PHMS;
DOI:10.1021/jo9613085
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) p-nitrobenzoic acid, Ph3P, DEAD; 2.) LAH / 1.) THF, -30 deg C to rt.; 2) THF
2: 1.) o-nitrophenol; 2.) LAH / 1.) 160 deg C; 2.) THF
3: 86 percent / Ph3P, CBr4 / CH2Cl2
4: 87 percent / tetrahydrofuran; hexamethylphosphoric acid triamide / -78 - 20 °C
5: 92 percent / 1N NaOH / methanol
6: 61 percent / bis(benzylidene)ethylenediamine, polymethylhydrosiloxane, acetic acid / (dba)3Pd2*CHCl3 / 1,2-dichloro-ethane
With
sodium hydroxide; lithium aluminium tetrahydride; polymethylhydrosiloxane; carbon tetrabromide; bis(benzylidene)ethylenediamine; acetic acid; triphenylphosphine; 2-hydroxynitrobenzene; diethylazodicarboxylate; 4-nitro-benzoic acid;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(96)00861-1
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 92 percent / 1N NaOH / methanol
2: 61 percent / bis(benzylidene)ethylenediamine, polymethylhydrosiloxane, acetic acid / (dba)3Pd2*CHCl3 / 1,2-dichloro-ethane
With
sodium hydroxide; polymethylhydrosiloxane; bis(benzylidene)ethylenediamine; acetic acid;
tris(dibenzylideneacetone)dipalladium(0) chloroform complex;
In
methanol; 1,2-dichloro-ethane;
DOI:10.1016/0040-4039(96)00861-1
