(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Base Information

Chemical Name:(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
CAS No.:202390-86-1
Molecular Formula:C₂₄H₂₁NO₅
Molecular Weight:403.434
Hs Code.:

Synonyms:(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Suppliers and Price of (2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Chemical Property:

Purity/Quality:: 99.90% ^*data from raw suppliers

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Technology Process of (2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

There total 7 articles about (2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 157826-10-3,949023-16-9
(2R,4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

: 202390-86-1,949023-16-9
(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:: (2R,4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid; With p-Anisaldehyde dimethyl acetal; (R)-10-camphorsulfonic acid; In toluene; at 20 - 130 ℃; Large scale;

With lithium hydroxide; In tetrahydrofuran; methanol; water; at 0 ℃; for 0.333333h; Large scale;

Reference yield: 83.0%

: 202390-85-0
Methyl (2S,4S,5R)-3-benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

: 202390-86-1,949023-16-9
(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:: With lithium hydroxide; water; In tetrahydrofuran; methanol; at 0 ℃; for 0.333333h;
DOI:10.1002/(sici)1521-3765(19990104)5:1<121::aid-chem121>3.3.co;2-f

Reference yield:

: 129320-33-8
5-Ethyl (2R,3R)-2-benzyloxy-3-hydroxy-3-phenylpropanethioate

: 202390-86-1,949023-16-9
(2S,4S,5R)-3-Benzoyl-2-(p-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) HN₃, Ph₃P, DEAD; 2.) PPh₃, H₂O / 1.) benzene, r.t.; 2.) THF, 55 deg C

2: 90 percent / DMAP / CH₂Cl₂ / 0 °C

3: 96 percent / SnCl₄ / CH₂Cl₂ / Heating

4: 84 percent / AgOCOCF₃ / Ambient temperature

5: 79 percent / CSA / toluene

6: 73 percent / LiOH, H₂O / methanol / Ambient temperature

With dmap; lithium hydroxide; tris-(2-chloro-ethyl)-amine; camphor-10-sulfonic acid; water; silver trifluoroacetate; tin(IV) chloride; triphenylphosphine; diethylazodicarboxylate; In methanol; dichloromethane; toluene;
DOI:10.1246/cl.1998.3