N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide
CAS No.:1443360-44-8
Molecular Formula:C₂₅H₂₂INO₂S₂
Molecular Weight:559.492
Hs Code.:

Synonyms:N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Suppliers and Price of N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

There total 4 articles about N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: C₁₂H₁₁BrS

: 61613-20-5
N-tosyl-2-iodoaniline

: 1443360-44-8
N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 3h;
DOI:10.1021/jo400567h

Reference yield:

: 1443359-64-5
methyl 5-benzylthiophene-3-carboxylate

: 1443360-44-8
N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

2: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C

3: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With phosphorus tribromide; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400567h

Reference yield:

: methyl 3-acetoxy-2-methylene-5-phenylpent-4-ynoate

: 1443360-44-8
N-((5-benzylthiophen-3-yl)methyl)-N-(2-iodophenyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium thioacetate; potassium carbonate / methanol / 18 h / 20 °C

2: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C

3: phosphorus tribromide / dichloromethane / 0.5 h / 0 °C

4: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

With phosphorus tribromide; diisobutylaluminium hydride; potassium carbonate; potassium thioacetate; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo400567h