2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

Base Information

Chemical Name:2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid
CAS No.:1420999-15-0
Molecular Formula:C₂₀H₂₁ClN₄O₅
Molecular Weight:432.864
Hs Code.:

Synonyms:2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

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Chemical Property of 2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

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Technology Process of 2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

There total 4 articles about 2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1421000-18-1
diethyl 2-(4-(3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino)piperidin-1-yl)malonate

: 1420999-15-0
2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

Guidance literature:: With sodium hydroxide; at 50 ℃; for 3h;

Reference yield:

: 1420998-90-8
N-(3-chlorophenyl)-2-(4-piperidylamino)nicotinamide

: 1420999-15-0
2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 24 h / Reflux

2: sodium hydroxide / 3 h / 50 °C

With potassium carbonate; sodium hydroxide; In acetonitrile;

Reference yield:

: 1420998-53-3
C₂₂H₂₇ClN₄O₃

: 1420999-15-0
2-{4-[3-(3-chlorophenylcarbamoyl)pyridin-2-ylamino]piperidin-1-yl}malonic acid

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / ethanol; water / 8 h / Reflux

2: potassium carbonate / acetonitrile / 24 h / Reflux

3: sodium hydroxide / 3 h / 50 °C

With hydrogenchloride; potassium carbonate; sodium hydroxide; In ethanol; water; acetonitrile;