4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride

Base Information

Chemical Name:4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride
CAS No.:122111-05-1
Molecular Formula:C9H11 F2 N3 O4 . Cl H
Molecular Weight:299.662
Hs Code.:
Mol file:122111-05-1.mol

Synonyms:2(1H)-Pyrimidinone,4-amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-, monohydrochloride (9CI)

Suppliers and Price of 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1’-EpiGemcitabineHydrochloride
50mg
$ 1455.00

TRC
1’-EpiGemcitabineHydrochloride
10mg
$ 340.00

Biosynth Carbosynth
1'-Epi gemcitabine, hydrochloride
5 mg
$ 300.00

Biosynth Carbosynth
1'-Epi gemcitabine, hydrochloride
2 mg
$ 150.00

Biosynth Carbosynth
1'-Epi gemcitabine, hydrochloride
1 mg
$ 95.00

Biosynth Carbosynth
1'-Epi gemcitabine, hydrochloride
25 mg
$ 1000.00

Biosynth Carbosynth
1'-Epi gemcitabine, hydrochloride
10 mg
$ 495.00

American Custom Chemicals Corporation
1'-EPI GEMCITABINE HYDROCHLORIDE 95.00%
100MG
$ 1963.50

American Custom Chemicals Corporation
1'-EPI GEMCITABINE HYDROCHLORIDE 95.00%
10MG
$ 750.75

Total 13 raw suppliers

Chemical Property of 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride

Chemical Property:

Melting Point:204-206°C
PSA：110.60000
LogP:0.09460
Storage Temp.:-20°C Freezer, Under Inert Atmosphere
Solubility.:Methanol (Slightly), Water (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

1’-EpiGemcitabineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses a-Anomer of Gemcitabine α-Anomer of Gemcitabine. 1’-Epi Gemcitabine Hydrochloride (Gemcitabine EP Impurity B) is an α-Anomer of Gemcitabine.

Technology Process of 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride

There total 2 articles about 4-Amino-1-(2-deoxy-2,2-difluoro-a-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 103882-84-4,103882-85-5
2’-deoxy-2’,2’-difluoro-cytidine

: 122111-05-1
2'-deoxy-2',2'-difluorocytidine hydrochloride

: 122111-03-9
gemcitabine hydrochloride

Guidance literature:: With hydrogenchloride; In water; isopropyl alcohol; at -4 - 60 ℃; for 6.5h;

Reference yield:

: 14631-20-0
4-N-Acetylcytosine

: 134877-42-2,134877-43-3,122111-11-9
3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose

: 122111-05-1
2'-deoxy-2',2'-difluorocytidine hydrochloride

: 122111-03-9
gemcitabine hydrochloride

Guidance literature:: 4-N-Acetylcytosine; With chloro-trimethyl-silane; 1,1,1,3,3,3-hexamethyl-disilazane; In 1,2-dichloro-ethane; for 3h; Heating / reflux;

3,5-di-O-benzoyl-2-deoxy-2,2-difluoro-1-O-methanesulfonyl-D-erythro-pentofuranose; With trimethylsilyl trifluoromethanesulfonate; In 1,2-dichloro-ethane; at 20 - 75 ℃; for 14 - 16h; Heating / reflux;

With hydrogenchloride; In water; 1,2-dichloro-ethane;