(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

Base Information

Chemical Name:(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane
CAS No.:625389-83-5
Molecular Formula:C₂₂H₂₆N₂O
Molecular Weight:334.461
Hs Code.:

Synonyms:(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

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Chemical Property of (1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

Chemical Property:

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Technology Process of (1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

There total 12 articles about (1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 939-89-9,939-90-2,3471-10-1,5685-38-1,23020-15-7,23020-18-0,42916-14-3,48126-51-8,67528-68-1,111956-00-4,111956-01-5
(1R)-1-carboxy-2-phenylcyclopropane

: 1013-76-9
1-(2,4-dimethylphenyl)piperazine

: 625389-83-5
(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1021/jo0302206

Reference yield:

: 63106-93-4,96847-52-8,96847-75-5,96847-53-9
(1S,5R)-1-phenyl-3-oxabicyclo[3.1.0]hexan-2-one

: 625389-83-5
(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

Guidance literature:: Multi-step reaction with 10 steps

1.1: Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

1.2: AlCl₃ / CH₂Cl₂ / 0 - 20 °C

2.1: imidazole / dimethylformamide / 15 h / 20 °C

3.1: DIBALH / CH₂Cl₂; hexane / 2 h / -78 °C

4.1: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / acetone; H₂O / 12 h / 20 °C

5.1: Bu₃P; t-BuSH / tetrahydrofuran / 20 °C

6.1: t-BuSH; Et₃B / tetrahydrofuran / 20 °C

7.1: TBAF / tetrahydrofuran / 12 h / 20 °C

8.1: tetrapropylammonium perruthenate; N-methylmorpholine N-oxide / CH₂Cl₂ / 0.5 h / 20 °C

9.1: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / acetone; H₂O / 15 h / 20 °C

10.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2 h / 0 - 20 °C

With 1H-imidazole; sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; triethyl borane; tributylphosphine; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; 2-methylpropan-2-thiol; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane; water; N,N-dimethyl-formamide; acetone; 6.1: Barton reductive radical decarboxylation;
DOI:10.1021/jo0302206

Reference yield:

: 936-98-1,1007-09-6,10488-04-7,29667-46-7,61826-40-2,79981-48-9,110659-58-0,139492-31-2
((R)-2-Phenyl-cyclopropyl)-methanol

: 625389-83-5
(1R,2S)-1-[4-(2,4-dimethylphenyl)piperazyl]carbonyl-2-phenylcyclopropane

Guidance literature:: Multi-step reaction with 3 steps

1: tetrapropylammonium perruthenate; N-methylmorpholine N-oxide / CH₂Cl₂ / 0.5 h / 20 °C

2: NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / acetone; H₂O / 15 h / 20 °C

3: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 2 h / 0 - 20 °C

With sodium chlorite; sodium dihydrogenphosphate; tetrapropylammonium perruthennate; 2-methyl-but-2-ene; 4-methylmorpholine N-oxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; acetone;
DOI:10.1021/jo0302206