N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine

Base Information

• Chemical Name: N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine
• CAS No.: 142068-14-2
• Molecular Formula: C₂₃H₂₉N₅O₃Si
• Molecular Weight: 451.6

Synonyms:N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine

Chemical Property of N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine

There total 6 articles about N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

N6-5'-O-(tert-butyldimethylsilyl)-2',3'-bis-O-<(methylthio)thiocarbonyl>adenosine (142068-13-1) → N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine (142068-14-2)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 1h; Heating;

DOI:10.1021/jm00093a003

Reference yield:

N6-benzoyl-5'-O-(tert-butyldimethylsilyl)adenosine (69504-16-1) → N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine (142068-14-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) NaH, imidazole / 1.) THF, 45 min, 2.) THF, 30 min

2: tetrahydrofuran / 0.5 h

3: 91 percent / tri-n-butyltin hydride, azobisisobutyronitrile / toluene / 1 h / Heating

With 1H-imidazole; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In tetrahydrofuran; toluene;

DOI:10.1021/jm00093a003

Reference yield:

Dithiocarbonic acid O-[(2R,3R,4R,5R)-5-(6-benzoylamino-purin-9-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-4-dithiocarboxyoxy-tetrahydro-furan-3-yl] ester → N6-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine (142068-14-2)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 0.5 h

2: 91 percent / tri-n-butyltin hydride, azobisisobutyronitrile / toluene / 1 h / Heating

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In tetrahydrofuran; toluene;

DOI:10.1021/jm00093a003

upstream raw materials:

N⁶-5'-O-(tert-butyldimethylsilyl)-2',3'-bis-O-<(methylthio)thiocarbonyl>adenosine

N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)adenosine

2'-deoxy-D-adenosine

N₆-benzoyl-2'-deoxyadenosine

Downstream raw materials:

Phosphoric acid (2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl ester phenyl ester; compound with ammonia

Phenyl-phosphonothioic acid O-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl] ester; compound with ammonia

Phenyl-phosphonic acid mono-[(2S,5R)-5-(6-amino-purin-9-yl)-2,5-dihydro-furan-2-ylmethyl] ester; compound with ammonia

N⁶-benzoyl-2',3'-didehydro-2',3'-dideoxyadenosine 5'-dimethyl phosphate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 142068-14-2 N⁶-benzoyl-5'-O-(tert-butyldimethylsilyl)-2',3'-didehydro-2',3'-dideoxyadenosine

Send

Send

Metric Ton KG G Pound L ML

Send

Send