2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Name:2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine
CAS No.:1443684-52-3
Molecular Formula:C₂₂H₁₆ClFN₆
Molecular Weight:418.861
Hs Code.:

Synonyms:2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Chemical Property of 2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

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Technology Process of 2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

There total 6 articles about 2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29241-60-9
5-bromo-2-chloro-3-methylpyridine

: 1443684-52-3
2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C

1.2: -78 - 20 °C

2.1: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 4 h / 110 °C

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 2 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; water; 3.1: |Suzuki Coupling;

Reference yield:

: 75399-07-4
methyl 3-oxo-3-(pyrazin-2-yl)propanoate

: 1443684-52-3
2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethanol / 10 h / Reflux

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

2.2: 1.5 h / 20 °C

3.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 2 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydride; potassium carbonate; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; mineral oil; 3.1: |Suzuki Coupling;

Reference yield:

: 6164-79-0
methyl pyrazine-2-carboxylate

: 1443684-52-3
2-(2-chloro-6-fluoro-phenyl)-5-(2-ethyl-5-pyrazin-2-yl-2H-pyrazol-3-yl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium methylate / methanol; toluene / 100 °C

2.1: ethanol / 10 h / Reflux

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / 0 - 20 °C

3.2: 1.5 h / 20 °C

4.1: potassium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water; 1,4-dioxane / 2 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium methylate; sodium hydride; potassium carbonate; In 1,4-dioxane; methanol; ethanol; water; N,N-dimethyl-formamide; toluene; mineral oil; 4.1: |Suzuki Coupling;