5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Base Information

Chemical Name:5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile
CAS No.:1266519-69-0
Molecular Formula:C₂₀H₁₁ClF₂N₄O₂S
Molecular Weight:444.849
Hs Code.:

Synonyms:5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

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Chemical Property of 5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

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Technology Process of 5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

There total 5 articles about 5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1266520-44-8
5-(3-chloro-5-fluorophenyl)-4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylic acid

: 1266519-69-0
5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 1266520-42-6
ethyl 4-(3-cyano-4-fluorophenyl)-1,3-thiazole-2-carboxylate

: 1266519-69-0
5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: bromine; potassium acetate; acetic acid / 48 h / 100 °C

2: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 20 °C / Reflux

3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; potassium acetate; sodium hydrogencarbonate; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 179897-89-3
5-Bromo-2-fluoro-benzonitrile

: 1266519-69-0
5-{5-(3-chloro-5-fluorophenyl)-2-[(4-oxoimidazolidin-1-yl)carbonyl]-1,3-thiazole-4-yl}-2-fluorobenzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / Inert atmosphere; Reflux

1.2: 4 h / 20 °C

2.1: bromine; hydrogenchloride; acetic acid / water / 1.5 h / 20 °C

2.2: 5 h / Reflux

3.1: bromine; potassium acetate; acetic acid / 48 h / 100 °C

4.1: sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 1 h / 20 °C / Reflux

5.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; bromine; potassium acetate; sodium hydrogencarbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,2-dimethoxyethane; water; toluene;