(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Base Information

Chemical Name:(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate
CAS No.:1314804-25-5
Molecular Formula:C₂₃H₂₄N₄O₇
Molecular Weight:468.466
Hs Code.:

Synonyms:(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

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Chemical Property of (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

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Technology Process of (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

There total 2 articles about (2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 15981-63-2
2',3',5'-tri-O-acetylnebularine

: 17933-03-8
m-tolylboronic acid

: 1314804-25-5
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: With ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid; In water; 1,2-dichloro-ethane; for 1h; under 760.051 Torr; regioselective reaction;
DOI:10.1002/ejoc.201700406

Reference yield:

: 5987-73-5
2',3',5'-O-triacetyl-6-chloroinosine

: 591-17-3
meta-bromotoluene

: 1314804-25-5
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

Guidance literature:: meta-bromotoluene; With magnesium; In tetrahydrofuran; for 1h; Reflux;

With Trimethyl borate; In tetrahydrofuran;

2',3',5'-O-triacetyl-6-chloroinosine; Further stages;
DOI:10.1016/j.tet.2011.09.082

Reference yield: 86.0%

: 591-50-4
iodobenzene

: 1314804-25-5
(2R,3R,4R,5R)-2-(acetoxymethyl)-5-(6-(m-tolyl)-9H-purin-9-yl)tetrahydrofuran-3,4-diyl diacetate

: 1284287-22-4
6-([4-methyl-1,1'-biphenyl]-2-yl)-9-β-D-(2',3',5'-tri-O-acetyl)ribofuranosyl-9H-purine

Guidance literature:: With silver(I) acetate; palladium diacetate; acetic acid; at 120 ℃; for 48h; regioselective reaction; Sealed tube; Inert atmosphere;
DOI:10.1021/ol200405w