N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

Base Information

Chemical Name:N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine
CAS No.:1260402-12-7
Molecular Formula:C₃₃H₃₀FN₄O₃P
Molecular Weight:580.598
Hs Code.:

Synonyms:N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

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Chemical Property of N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

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Technology Process of N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

There total 11 articles about N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1260402-71-8
N-(4-(3-fluorobenzyloxy)-3-(2-(triisopropylsilyl)ethynyl)phenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

: 1260402-12-7
N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

Guidance literature:: With cesium fluoride; In N,N-dimethyl-formamide; at 50 ℃; for 2h;

Reference yield:

: 98556-31-1
4-chloro-6-iodoquinazoline

: 1260402-12-7
N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: isopropyl alcohol / 12 h / Reflux

2.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol / 4 h / 75 °C / Inert atmosphere

3.1: dichloromethane

3.2: 20 °C

4.1: cesium fluoride / N,N-dimethyl-formamide / 2 h / 50 °C

With potassium carbonate; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 701-45-1
2-bromo-1-fluoro-4-nitrobenzene

: 1260402-12-7
N-(4-(3-fluorobenzyloxy)-3-ethynylphenyl)-6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: pyrrolidine; copper(l) iodide / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C

3.1: acetic acid; iron / ethanol / 3 h / Reflux

4.1: isopropyl alcohol / 12 h / Reflux

5.1: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane; ethanol / 4 h / 75 °C / Inert atmosphere

6.1: dichloromethane

6.2: 20 °C

7.1: cesium fluoride / N,N-dimethyl-formamide / 2 h / 50 °C

With pyrrolidine; copper(l) iodide; iron; potassium carbonate; acetic acid; cesium fluoride; bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,2-dimethoxyethane; ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetone;