2-[2-(Bromomethyl)phenyl]ethanol

Base Information

• Chemical Name: 2-[2-(Bromomethyl)phenyl]ethanol
• CAS No.: 122444-35-3
• Molecular Formula: C9H11 Br O
• Molecular Weight: 215.09
• DSSTox Substance ID: DTXSID60515605
• Wikidata: Q82376557
• Mol file: 122444-35-3.mol

Synonyms:122444-35-3;2-[2-(Bromomethyl)phenyl]ethanol;Benzeneethanol, 2-(bromomethyl)- (9CI);2-(2-(Bromomethyl)phenyl)ethan-1-ol;2-[2-(Bromomethyl)phenyl]ethan-1-ol;2-(2-bromomethylphenyl)ethanol;SCHEMBL9140201;DTXSID60515605

Chemical Property of 2-[2-(Bromomethyl)phenyl]ethanol

Chemical Property:

• PSA: 20.23000
• LogP: 2.11630
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 213.99933
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CCO)CBr

Technology Process of 2-[2-(Bromomethyl)phenyl]ethanol

There total 5 articles about 2-[2-(Bromomethyl)phenyl]ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(bromomethyl)phenethyl acetate → 2-(2-bromomethyl)-phenethyl alcohol (122444-35-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201407185

Reference yield: 72.0%

2-(2-hydroxyethyl)benzyl alcohol (6346-00-5) → 2-(2-bromomethyl)-phenethyl alcohol (122444-35-3)

Guidance literature:

With hydrogen bromide; In water; at 20 ℃; for 3h;

Reference yield: 63.5%

isochromane (493-05-0) → 2-(2-bromomethyl)-phenethyl alcohol (122444-35-3)

Guidance literature:

With hydrogen bromide; for 17h; Ambient temperature;

DOI:10.1021/jm00128a028

upstream raw materials:

isochromane

2-(2-hydroxyethyl)benzyl alcohol

isochroman-3-one

Downstream raw materials:

1-(Bromomethyl)-2-[2-(trimethylsilyloxy)ethyl]benzene

1-(2-bromo-ethyl)-2-bromomethyl-benzene

vinylbenzyl bromide

3,4-dihydro-1H-spiro[isoquinoline-2,1'-piperidinium]; bromide

Refernces

• 1、 -. "POLYNUCLEOTIDE CONSTRUCTS HAVING BIOREVERSIBLE AND NON-BIOREVERSIBLE GROUPS". Page/Page column 89. . Retrieved 2016/02/19.
• 2、 Shcheglova,Kolesnik,Ashirov. "General procedure for the synthesis of ortho-vinylbenzyl-substituted amines, ethers, and sulfides". . p. 1329 - 1334. Retrieved 2013/11/06.